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 Biography   Alan Frazer, Ph.D. Professor and Chairman, Department of Pharmacology University of Texas Health Science Center at San Antonio Dr. Frazer’s primary research interest is the mechanisms of action of anti-depressants. Using mostly an in vivo approach, he and his colleagues measure in experimental animals the effects produced by various types of antidepressants: on noradrenergic or serotonergic neurons, on neurochemical or behavioral responses elicited by these neurotransmitters, or on their receptors. Neuroanatomical localization of drug-induced effects is emphasized by employing techniques such as quantitative autoradiography, immunohistochemistry and in vivo voltammetry. Most of the laboratory’s recent work has used the latter technique, an electrochemical means to measure the rate of clearance of serotonin from extracellular fluid in discrete regions of the brain. Dr. Frazer also carries out clinical studies directed at clarifying the onset and timing of behavioral improvement induced by antidepressants. This work has demonstrated that behavioral improvement begins earlier than had been considered, and this has both theoretical and practical implications. In addition to his post at the University of Texas, Dr. Frazer has been a Career Scientist of the Department of Veterans Affairs. Dr. Frazer joined NARSAD’s Scientific Council in 1995. |
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