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 Biography   Anthony A. Grace, Ph.D. Professor of Neuroscience, Psychiatry and Psychology University of Pittsburgh Dr. Grace's research lies at the interface of neurobiology and psychiatry. Experiments in his laboratory combine in vivo and in vitro electrophysiological recordings of neurons with behavioral and neuroanatomical techniques to study central dopaminergic systems. (The neurotransmitter dopamine plays a role in schizophrenia and other disorders.) Dr. Grace’s ultimate goal is to determine the neurobiological correlates of mental disorders and the modes of action of psychotherapeutic drugs. Studies in Dr. Grace’s laboratory of the neurobiology of schizophrenia involve the interaction of the prefrontal cortex and antipsychotic drugs with subcortical dopamine systems, and the impact of developmental disruption on limbic-system function as a model for the pathophysiological changes underlying schizophrenia. Additional studies are examining plasticity in the limbic system, the site of brain structures involved in emotion. The particular focus is on response in the amygdala to chronic stress exposure and to drugs of abuse. These analyses, using animal models of drug addiction, craving and affective disorders, are based on electrophysiological, anatomical, neurochemical and behavioral studies. Dr. Grace received a NARSAD Distinguished Investigator Award in 1998, and was elected to NARSAD’s Scientific Council in 2000. |
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