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 Research & Giving News Article  Brain's Reward Center Finding may help explain addiction tendencies In their study of 45 subjects, Ahmad Hariri, Ph.D., and colleagues at the University of Pittsburgh and collaborators at Mount Sinai School of Medicine and the University of Chicago showed that activity in the ventral striatum, a core component of the brain's reward circuitry, correlated with individuals' impulsiveness. Dr. Hariri is a NARSAD Young Investigator with a grant from 2003 that is still active. "These data are exciting because they begin to unravel individual differences in brain organization underlying differences in complex psychological constructs, such as 'impulsivity,' which may contribute to the propensity to addiction," says Terry E. Robinson, Ph.D., of the University of Michigan biopsychology program. The Hariri team tested the subjects on two computer-based tasks. First, participants indicated their preferences in a series of immediate-versus-delayed, hypothetical monetary rewards. They chose between receiving an amount from 10 cents to $105 that day and receiving $100 at one of seven points up to five years in the future. "Switch points"—the value at which they were equally likely to choose getting money today as getting $100 at a future point in time—were calculated for each person. Seven months later, subjects were told they could win money if they correctly guessed numbers on a series of cards while scientists used blood oxygenation-level dependent (BOLD) functional magnetic resonance imaging (fMRI) to measure brain activity in response to correct and incorrect guesses. These images reflected participants' reactions to positive and negative "reward" feedback. After matching images to the subjects' switch points on the index of impulsiveness, the researchers looked for patterns. Individuals indicating the strongest preference for immediate over delayed rewards showed the most ventral striatum activity associated with positive and negative feedback for a monetary reward. "Our findings suggest that the ventral striatum plays a key role in striking a balance between gratification and delay, impulsive action and prudent choice, that can have far-reaching implications for our current and future well-being," says Hariri. The team aims to examine the role of specific factors that drive the sensitivity of the ventral striatum next. One target of future research will be genes that regulate levels of the neurotransmitter dopamine and how they vary among individuals, Hariri says. Research and investigator funding were provided by the National Institutes of Health and NARSAD: The Mental Health Research Association. The Journal of Neuroscience is published by the Society for Neuroscience, an organization of more than 36,500 basic scientists and clinicians who study the brain and nervous system. The Society for Neuroscience gave NARSAD: The Mental Health Research Association permission to reprint the above press release. |
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