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 Project Summary  Ravi Allada, M.D. (Young Investigator 2003) of Northwestern University, is examining the genetic components involved in alterations in biological clocks that regulate daily rhythms. These alterations are implicated in bipolar disorder. Using a fruit fly model (Drosophila melanoaster), Dr. Allada will study a gene (DmlaU) that regulates brain function, and in humans, maps to a chromosomal region that contributes to bipolar disorder. Additionally, mood stabilizers used to treat bipolar disorder, such as lithium and valproate, alter daily rhythms in the fly. Dr. Allada will investigate if this gene is functioning within the circadian pacemaker and if it may mediate the behavioral effects of lithium and valproate. This study will elucidate the biological function of this gene and its role in mediating therapeutic effects of mood stabilizers. Program Area: MOOD DISORDERS\Bipolar |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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