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 Project Summary  Patrick Allen, Ph.D. (Young Investigator 2003) of Connecticut Mental Health Center, will examine the effects of dopamine on movement of the glutamate receptor to the surface of neurons. One of the major biochemical targets of dopamine is a “phosphatase” enzyme, which breaks off phosphate groups. Dr. Allen will examine the influence of this phosphatase on the regulation of glutamate receptor cell surface occupancy. This will be achieved with the use of genetically modified mouse strains in which the relevant genes for the phosphatase have been removed. These animals will receive a series of drug treatments that are known to influence dopamine and glutamate neurotransmission. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia\Pharmacology |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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