Project Summary

Stewart A. Anderson, M.D. (Young Investigator 2002) of Weill Medical College of Cornell University, is investigating the inhibitory interneurons of the cerebral cortex.  Although these cells are a minority of the cortical neurons, they play a vital role in regulating cortical output.  Interneuron dysfunction has been implicated in a variety of psychiatric illnesses, including anxiety disorders, depression and schizophrenia.  Interestingly, there are many subtypes of cortical interneurons, which differ dramatically in the shape and connectivity of their processes, in their expression of various chemical markers, and in their effects on cortical function.  The goal of his research is to understand how the diversity of cortical interneurons is generated.  By assessing the maturation of transplanted neurons, Dr. Anderson expects to gain molecular insights into the development of cortical interneurons which are crucial in regulating cerebral cortical function.

Program Area: MULTIPLE FOCUS AREAS\Schizophrenia/Mood Disorders/Anxiety Disorders

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