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 Project Summary  Jon R. Backstrom, Ph.D. (Young Investigator 2000) of Vanderbilt University, is investigating mechanisms by which LSD acts on biochemical systems in the brain. Specifically, he is attempting to determine why rat brain cells, unlike human brain cells, do not release calcium when stimulated by LSD, which acts at the 5-HT-2C receptor. Dr. Backstrom will make rat receptors that contain different regions of the human 5-HT-2C receptor to assess whether this function is improved, then changes will be made in the receptor to result in loss of this function. Findings that may be revealed by this study have the potential to lead to discovery of a new mechanism which dampens calcium levels inside the brain cell. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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NARSAD Award Winners
 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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