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 Project Summary  Vaishali P. Bakshi, Ph.D. (Young Investigator 2007) of the University of Wisconsin, Madison, will use animal models of prepulse inhibition (PPI) to determine the mechanisms underlying stress-induced cognitive impairment in schizophrenia. Previous work indicates that stimulating corticotropin-releasing factor (CRF) or norepinephrine (NE) systems disrupts PPI. Because CRF and NE reciprocally regulate each other and stress exposure causes release of both transmitters in the brain, Dr. Bakshi will test the hypothesis that CRF-NE interactions underlie the impairment in PPI observed after stress. Ultimately, her work may assist in identifying novel treatment strategies targeting these systems to "protect" schizophrenia patients from the deleterious effects of intense stressors. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator