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 Project Summary  Thomas A. Bayer, Ph.D. (Young Investigator 2000) of University of Bonn, is investigating a gene product called TIEG, which has been shown to be abnormally up-regulated in the brains of patients with mood disorders. Excessive TIEG could play a role in the loss of a particular cell in the brain called the astrocyte. Previous work suggests that patients with mood disorders have less astroglial cells in the prefrontal cortex. Dr. Bayer will analyze the quantity of TIEG messenger RNA in the prefrontal cortex deriving from a post-mortem brain bank of patients with mood disorders, schizophrenia, and controls. In addition, the effect of turning on the TIEG gene on the astroglial cell will be examined. This work has the potential to lead to a better understanding of the genetics and neuropathology of mood disorders. Program Area: MULTIPLE FOCUS AREAS\Schizophrenia/Bipolar |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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