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 Project Summary  Joseph F. Cubells, M.D., Ph.D. (Independent Investigator 2005) of Emory University School of Medicine , plans to use the latest genetics technology to understand why approximately 30 percent to 40 percent of people who take interferon-alpha, a commonly used treatment for hepatitis C and malignant melanoma, develop major depression symptoms. Dr. Cubells aims to identify the genes that make some people more vulnerable to interferon-alpha-induced depression. He will examine structural differences ("polymorphisms") in those genes that encode molecules known to be important in the actions of interferon as prime candidate genes in interferon-induced depression. DNA samples and data about mood symptoms before and after treatment will be gathered from patients for whom interferon treatment is indicated. Dr. Cubells expects to generate sufficient data to support an application for federal support of a larger study of this issue in depression research. Program Area: MOOD DISORDERS\Unipolar |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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