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Melanie Darstein, Ph.D. (Young Investigator 2001) of Salk Institute for Biological Studies, aims to investigate the interactions between the proteins GBAP and KA1 in biochemical, anatomical, and electrophysiological experiments. KA1 is a receptor subtype of kainite, a substance which regulates the release of glutamate from nerve terminals. The GBAP protein is associated with KA1 and may also regulate glutamate release. This work may prove to be important in schizophrenia, because glutamate function in decreased in the hippocampus in these patients. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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