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 Project Summary  Ralph J. DiLeone, Ph.D. (Young Investigator 2004) of the University of Texas Southwestern Medical Center at Dallas, points out that the lateral hypothalamus and the nucleus accumbens have been studied for their role in the regulation of emotions and response to reward. Dr. DiLeone has found that the neuropeptide MCH mediates interactions between these brain regions, and signaling of the receptor for MCH in the nucleus accumbens can modulate depression in laboratory animals. He proposes studying how MCH mediates mood by genetically engineering a mouse without the MCH gene and to see the animal’s response. He further plans to study the mechanism of the receptor for MCH by investigating the effects of MCH signaling on specific phosphoproteins in the nucleus accumbens. The results could help establish the relationship between neuropeptides and mood and provide pathways for novel targets in developing antidepressant therapies. Program Area: MOOD DISORDERS\Unipolar Depression |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator