Project Summary

Grigori Enikolopov, Ph.D. (Independent Investigator 2004) of Cold Spring Harbor Laboratory, using a mouse model, will attempt to develop and approach for quantitative assessment and comparison of the properties of neural stem cells, as it is necessary for new neurons to be generated from stem cells in the brain in order for antidepressant drugs to work. Neural stem cells role in the functioning adult brain is still unclear and Dr. Enikolopov will study neural cells at various stages of their differentiation program to ascertain the effects antidepressant drugs on neural stem cells. He will also assess the properties of stem cells after they are transplanted into a lesioned nervous system. These studies will allow for rigorous measurements of what happens to neural stem cells in the adult brain and will further understanding of the cellular basis of depression.

Program Area: MOOD DISORDERS\Bipolar

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