Project Summary

Loubna Erraji-Benchekroun, Ph.D., L.E. (Young Investigator 2003) of New York State Psychiatric Institute, will use two knockout mice models of aggression and impulsivity to discover new candidate molecules, either in the serotonin system or in related systems that are altered in both models and might mediate human aggression. She will use DNA microarray technology that allows identifying genes whose expression is altered, and generates panels of thousands of transcription biomarkers that can be related to biological functions, such as brain dysfunction. Understanding aggression and impulsivity may help in devising new approaches to the treatment of individuals with major depression and personality disorders with a history of suicidal behavior.

Program Area: MULTIPLE FOCUS AREAS\Suicide/Aggression/Impulsivity

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