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 Project Summary  Aygun Ertugrul, M.D. (Young Investigator 2002) of Vanderbilt University, will attempt to replicate her previous finding that certain genetic variations (involving two receptors for the neurotransmitter serotonin) which are called single nucleotide polymorphisms (SNPs) may predict the cognitive response to clozapine. Dr. Ertugrul hopes to show this finding to be accurate, and to determine if these receptors also predict the response to treatment with risperidone and olanzapine, the two most widely used antipsychotic drugs. If successful, the study will increase understanding of the role of serotonin and dopamine in the etiology of schizophrenia and suggest pharmacologic strategies to enhance cognition in schizophrenia. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator