Project Summary

Seth Friedman, Ph.D. (Young Investigator 2000) of University of Washington, is examining metabolic abnormalities of the brain that may underlie panic disorder.  The proposal seeks to utilize a novel spectroscopic approach called proton-decoupled phosphorous spectroscopy to provide measures of metabolites that are suspected to be altered in patients with panic disorder who are administered lactate infusion and/or hyperventilation.  Previous research has demonstrated that panic disorder patients are highly likely to have a panic attack following both lactate and hyperventilation, but the mechanisms underlying this are unclear.  These studies will allow the evaluation of several potentially abnormal mechanisms of panic disorder, including energy substrate utilization, and lactate production and clearance.

Program Area: ANXIETY DISORDERS\Panic Disorder

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