Project Summary

Mary-Claire King, Ph.D. (Distinguished Investigator 2006) of the University of Washington, will take a novel approach in seeking to determine the identification of schizophrenia genes. Dr. King believes some mutations leading to schizophrenia are individually very rare, and that these rare mutations may serve as “indicator mutations” to reveal genes harboring other alleles associated with the disease. She notes that two types of mutations are detectable--genomic deletions or duplications of several thousand base pairs and expanding triplet repeats. Using a technique developed by a colleague called Representational Oligonucleotide Microarray Analysis, she will evaluate two series of schizophrenia cases enriched for persons most likely to harbor such mutations. If successful, this genomics strategy will provide important information on the genetics of schizophrenia.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

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