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Gina R. Kuperberg, M.D., Ph.D. (Young Investigator 2003) of Massachusetts General Hospital, is investigating the relationship between the thickness of the cerebral cortex and functional brain activity in patients with schizophrenia. Both structural disturbances of the brain and abnormalities in thought and language processes have been demonstrated in this disorder. New methods will be applied to “unfold” the cerebral cortex to measure the thickness of each point of the entire unfolded cortical surface. Functional brain activity will be quantified during the performance of language tasks. Preliminary work from Dr. Kuperberg indicates that the same brain regions with abnormally low activity also have reduced cortical thickness. Visit Dr. Kuperberg's lab website at: http://kuperberglab.nmr.mgh.harvard.edu/. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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