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 Project Summary  Mark L. Laudenslager, Ph.D. (Independent Investigator 2005) of the University of Colorado Health Sciences Center, aims to study whether dysregulation of the hormones released by the hypothalamic pituitary adrenal (HPA) axis plays a role in early onset bipolar disease and whether a certain intervention might help these youngsters. Daily rhythms of HPA hormones, for example, are disrupted and elevated in depression and reduced in post traumatic stress disorder, but little is known about HPA in bipolar disease in adolescents. Using a device that permits simple, portable, and noninvasive collection of biomarkers of the hypothalamic-pituitary-adrenal axis, the researchers in this project plan to record daily rhythms of two hormones, cortisol and DHEA, in adolescents with bipolar disease and correlate the biomarkers with the effect of treatment. They hope to determine if they can correlate biomarkers and treatment success. The treatment is a focused family psycho-educational intervention. Program Area: MOOD DISORDERS\Bipolar |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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