Project Summary

Bridget C. Lear, Ph.D. (Young Investigator 2007) of Northwestern University, will investigate the way in which a unique gene called narrow abdomen functions in nerve cells. The gene is believed to encode a protein channel for communication between neurons. The human version of narrow abdomen lies in a region of the genome associated with bipolar disorder and schizophrenia. Dr. Lear’s laboratory has developed a system in the fruit fly drosophila to study modified, but still functional, versions of narrow abdomen. Since drosophila and human versions of narrow abdomen are very similar, this research is likely to be applicable to understanding the human gene as well.

Program Area: MULTIPLE FOCUS\Mood Disorders/Schizophrenia\Sleep Disorders

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