Project Summary

Sarah H. Lisanby, M.D. (Independent Investigator 2003) of Columbia University, will explore the efficacy of Magnetic Seizure Therapy (MST) as a treatment for major depression (unipolar and bipolar), and explore the efficacy of two forms of MST. MST is the use of transcranial magnetic stimulation (TMS) to induce a seizure, under anesthesia, and may be used as an alternative to using electroconvulsive therapy (ECT). Though ECT is highly effective, it is limited by side effects like memory loss. MST uses magnetic fields to pass through the scalp and skull freely, providing better control over dosage and location of stimulation. Dr. Lisanby’s previous work has shown MST to be effective in individuals with major depression and has significantly milder side effects. Though the current MST device cannot yet deliver the optimal dosage to the prefrontal cortex, Dr. Lisanby will now test the efficacy of a new device and compare two forms of MST (one with a coil that focuses seizures in the prefrontal cortex and the other that uses a coil to provide nonfocal stimulation of broad areas). She will compare her results against ongoing ECT trials at New York State Psychiatric Institute using similar methods. She believes MST may offer fewer side effects and improved efficacy in the treatment of people with major depression and other disorders.

Program Area: MOOD DISORDERS\Unipolar Depression

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