Project Summary

Roger S. McIntyre, M.D. (Independent Investigator 2007) of the University of Toronto, is studying neurocognitive difficulties (concentration, memory, attention, and learning) in people with Major Depressive Disorder (MDD). Insulin, best known for its effect on glucose regulation, is a critical protein in the brain that balances brain chemical transmitters, stimulates brain growth, and enhances brain cell survival, learning and memory. Animal studies indicate that the administration of insulin protects the brain from injury and improves memory. This investigation will attempt to determine if intranasal insulin improves memory and other aspects of neurocognitive function in individuals with MDD who do not have any apparent depressive symptoms. If effective, intranasal insulin could become a novel and innovative treatment for neurocognitive difficulties with potential to improve a depressed individual’s quality of life and function.

Program Area: MOOD DISORDERS\Unipolar

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