Project Summary

Stephane H. R. Oliet, Ph.D. (Independent Investigator 2007) of INSERM, University Victor Segalen Bordeaux II, observes that a dysfunction of communication between neurons is a common feature of numerous neurological disorders. Studies performed in the last decade have revealed that glial cells are actively involved in neuronal communication. These glial cells release d-serine which is essential for NMDA glutamate receptor activation. Because these receptors are implicated in many physiological and pathological processes, it is crucial to establish the contribution of glial d-serine to brain signaling. The proposed project seeks to do precisely this.

Program Area: OTHER\Memory Disorders

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