Project Summary

John C. Roder, Ph.D. (Distinguished Investigator 2006) of The University of Toronto, is studying the genetics of schizophrenia. He notes that while it is widely accepted that many genes likely contribute to schizophrenia, no agreement exists as to which ones are implicated. He proposes to validate one likely gene by genetically engineering mice carrying mutations in the candidate gene known as disruption-in-schizophrenia gene (DISC1). He is in an excellent position to develop this model, as he has identified the very first DISC-1 mutants in the mouse, using a reverse genetics approach, in collaboration with a lab in Japan. The two mutants share similar measurable symptoms with people with schizophrenia, and others will be tested during the course of this project. Additionally, if they are a valid model for schizophrenia, behavioral symptoms should be reversed by antipsychotics. Dr. Roder believes his use of new technology will elucidate how mutations in DISC1 lead to schizophrenia-like behaviors in mice at various levels—the electrophysiological, synaptic, developmental, neuropathological, and behavioral. This work is important as it may validate the DISC1 gene as a viable candidate for schizophrenia

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

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