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 Project Summary  Cheryl A. Rogers, Ph.D. (Young Investigator 2001) of Salk Institute for Biological Studies, will attempt to identify synaptic proteins that interact with a protein called DISC1, the gene for which has been associated with schizophrenia. Preliminary data suggest that DISC1 interacts with glutamate receptors. Sophisticated genetic methods, including the yeast two-hybrid system, biochemical assays, and immunohistochemistry will be used. The neuronal expression pattern of the interacting proteins will be analyzed, potentially elucidating the signaling pathways involving DISC1. This work may shed light upon the mechanisms involved in schizophrenia. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator