Project Summary

Brian D. Ross, M.D., FRCS, FRCPath, D.Phil. (Distinguished Investigator 2003) of Huntington Medical Research Institute, will seek to determine if the neuronal function, glial function, and their interactions are abnormal in schizophrenia.  It has been previously established that people with schizophrenia show consistent structural and volumetric differences in the brain.  A new imaging technique, Carbon-13 Magnetic Resonance Spectroscopy or 13 C MRS, has not previously been applied to such a complex human brain disorder, and Dr. Ross proposes to utilize this new technique to study biochemical deficits in the brain and the impact of successful drug therapy.  He will study patients in a 300-bed community hospital and specialized Psychiatric Unit, and hopes his discoveries will lead to the development of future improved pharmacological treatments.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia\First-Episode Psychosis\Pharmacology

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