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 Project Summary  Luca Santarelli, M.D. (Young Investigator 2000) of Columbia University, is investigating a possible role of “neurogenesis” (new nerve cell growth) in the hippocampus in the therapeutic action of antidepressants. In addition, he aims to identify genes that elicit and maintain neurogenesis or other changes required for antidepressant efficacy. Previous work suggests that the serotonin type 1A (5HT-1A) receptor mediates effects of antidepressants on behavioral and molecular changes in abnormalities thought to underlie depression. These abnormalities include decreases in specific nerve growth factors and reduced neurogenesis in the hippocampus. This work may help elucidate the biochemical mechanisms underlying the effectiveness of antidepressants. Program Area: MOOD DISORDERS\Depression (Unipolar) |
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NARSAD Award Winners
 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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