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 Project Summary  Nathan Andrew Shapira, M.D., Ph.D. (Young Investigator 2001) of University of Florida, is evaluating the effectiveness and safety of a medication called tramadol, compared to the atypical antipsychotic risperidone in the treatment of outpatients with Tourette's Syndrome. Tramadol binds to opiate receptors and blocks the reuptake of norepinephrine and serotonin; previous work suggests that the symptoms of Tourette's are modulated by the opiate system. Patients will be randomized to either treatment, and will be studied in a double-blind design. This work may provide a possible new treatment for Tourette's syndrome. Program Area: MULTIPLE FOCUS AREAS\Tourette's Syndrome/OCD\Pain |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator