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 Project Summary  Zan-Min Song, M.Med., Ph.D. (Young Investigator 2000) of Australian National University, proposes to examine the role of the dopamine type 1 (D1) receptor on levels and phosphorylation states of two proteins that make up the “cytoskeleton” of the nerve cell. These proteins are called microtubule associated protein (MAP2) and glial fibrillary acidic protein (GFAP). The cytoskeleton is important in regulating the growth of nerve cells in the developing brain. In this study, mice will be used that either lack or over-express the D1 receptor. This study is pertinent to elucidating the causes of schizophrenia, in which abnormalities of the D1 receptor have been demonstrated. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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Mei Huang, Ph.D., Vanderbilt University Medical Center, 2005 & 2007 Young Investigator