Project Summary

Tianlai Tang, M.D., Ph.D. (Young Investigator 2003) of Vanderbilt University,   will seek to develop measurement techniques for the antipsychotic drug-induced prolongation of the QTc interval, which is a topic of keen interest in schizophrenia because some antipsychotic drugs have been either withdrawn from clinical use or else labeled with warnings that have greatly reduced their use.  Many potentially useful drugs are dropped early in development because of concern about QTc prolongation.  The validity of these concerns depends upon the validity of the measurement of the QTc interval.  Dr. Tang seeks to obtain reliable data concerning QTc prolongation, which will validate the method and provide the pilot data for power analysis to the sample sizes needed for a definitive study of specific drugs such as ziprasidone. 

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

Search Again