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 Project Summary  Daniel R. Weinberger, M.D. (Distinguished Investigator 2000) of National Institute of Mental Health (NIMH/NIH), is conducting a search for genes that increase susceptibility for schizophrenia in 400 sibling pairs. Levels of the brain chemical n-acetyl-aspartate (NAA) will be examined as an intermediate phenotype for targeted genetic association studies of schizophrenia. Reduced levels of NAA, a neurochemical measure related to the integrity of glutamate neurons, have been found in the hippocampus in patients with schizophrenia and their unaffected siblings. Dr. Weinberger will test candidate genes which relate to NAA levels and other biological phenotypes of schizophrenia, for associations with these variables in schizophrenia patients and their well siblings. This work has the potential to identify genes that play a role in the causation of schizophrenia. Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia |
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 Colleen Ann McClung, Ph.D., UT Southwestern Medical Center at Dallas, 2005 & 2007 Young Investigator Latest News from NARSAD
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