Project Summary

Jennifer E. Whistler, Ph.D. (Young Investigator 2000) of Ernest Gallo Clinic & Research Center, will examine the structure and function of G protein-coupled receptors.  These receptors constitute a diverse and physiologically important class of receptors, as they mediate the actions of a large number of neurotransmitters implicated in schizophrenia and depression.  Among the work proposed, structural aspects of these receptors will be defined.  These studies have the potential to elucidate a fundamental mechanism of receptor regulation relevant to the pathophysiology of schizophrenia and depression.  The studies may also identify new molecular targets for development of antipsychotic or antidepressant medications.

Program Area: SCHIZOPHRENIA/PSYCHOTIC DISORDERS\Schizophrenia

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